CD28 Function: A Balance of Costimulatory and Regulatory Signals
- 1 January 2002
- journal article
- review article
- Published by Springer Nature in Journal of Clinical Immunology
- Vol. 22 (1) , 1-7
- https://doi.org/10.1023/a:1014256417651
Abstract
Both the recognition of MHC/antigen complex by the T-cell receptor and engagement of costimulatory molecules are necessary for efficient T-cell activation. CD28 has been widely recognized as the...Keywords
This publication has 68 references indexed in Scilit:
- Development of Spontaneous Autoimmune Peripheral Polyneuropathy in B7-2–Deficient Nod MiceThe Journal of Experimental Medicine, 2001
- Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.Journal of Clinical Investigation, 1997
- High Concentrations of Antigenic Ligand Activate and Do Not Tolerize Naive CD4 T Cells in the Absence of CD28/B7 CostimulationCellular Immunology, 1997
- CD28/B7 Regulation of Th1 and Th2 Subsets in the Development of Autoimmune DiabetesPublished by Elsevier ,1996
- Duration of TCR Stimulation Determines Costimulatory Requirement of T CellsImmunity, 1996
- CD28/B7 SYSTEM OF T CELL COSTIMULATIONAnnual Review of Immunology, 1996
- Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4Science, 1995
- Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4Immunity, 1995
- Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseasesImmunology Today, 1995
- Treatment of Murine Lupus with CTLA4IgScience, 1994