In Vitro Study of Inline Filtration of Medications Commonly Administered to Pediatric Cancer Patients

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Abstract
Intravenous administration of drugs commonly used in patients with acute nonlymphocytic leukemia was simulated using a.22 μm air‐eliminating filter. Drug concentrations were measured pre‐ and postfiltration using standard pediatric drug doses and concentrations. The percentage of administered dose recovered in the postfilter sample for chemotherapy drugs was adriamycin, 92%; dactinomycin, 87%; cytarabine, 96%; and vincristine, 90%. For antibiotics, the per cent recovery was carbenicillin, 90%; cephalothin, 96%; and gentamicin, 38%. Gentamicin, and perhaps other drugs evaluated, should not be administered through a filter of the type used in this study.

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