Drug Fever

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Abstract
To the editor: Drug fever is an underdiagnosed situation in part due to nonspecific clinical characteristics as reported by Mackowiak and LeMaistre (1). They wrote that ". . . any drug has the capacity to induce fever. . . . the list is a dynamic one. . . ." We have seen fever as the sole feature of adverse drug reaction by another two drugs not listed by them, (+)-cyanidanol-3 and azathioprine. (+)-Cyanidanol-3 is a flavonoid used to treat chronic liver disease (2), which induces fever, probably by an immunologic mechanism (3). We have previously reported (4) two men with
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