Sequence Analyses of Cyanobacterial Bicarbonate Transporters and Their Homologues
- 1 July 2004
- journal article
- research article
- Published by S. Karger AG in Microbial Physiology
- Vol. 7 (3) , 102-108
- https://doi.org/10.1159/000078653
Abstract
The primary HCO3– uptake system in the cyanobacterium Synecocystis is the Na+-dependent transporter SbtA. SbtA and its homologues were identified and shown to display a common topology of ten transmembrane segments (TMSs). These proved to have arisen by an intragenic duplication event from an ancestral gene encoding a five TMS protein product. A region of SbtA shows sufficient similarity to 10 TMS ABC-type integral membrane transport proteins to suggest a common origin. Phylogenetic analyses of the SbtA family revealed two clusters of cyanobacterial homologues with all non-cyanobacterial family members outside of these two clusters. The tree topology suggests that SbtA family members display multiple transport functions.Keywords
This publication has 25 references indexed in Scilit:
- An ABC transporter with a secondary-active multidrug translocator domainNature, 2003
- Reversible Topological Organization within a Polytopic Membrane Protein Is Governed by a Change in Membrane Phospholipid CompositionPublished by Elsevier ,2003
- Inorganic Carbon Limitation and Light Control the Expression of Transcripts Related to the CO2-Concentrating Mechanism in the Cyanobacterium Synechocystis sp. Strain PCC6803Plant Physiology, 2003
- Web-Based Programs for the Display and Analysis of Transmembrane α-Helices in Aligned Protein SequencesMicrobial Physiology, 2003
- Genes Essential to Sodium-dependent Bicarbonate Transport in CyanobacteriaJournal of Biological Chemistry, 2002
- Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. CohenJournal of Molecular Biology, 2001
- Two Types of Functionally Distinct NAD(P)H Dehydrogenases inSynechocystis sp. Strain PCC6803Journal of Biological Chemistry, 2000
- Principles governing amino acid composition of integral membrane proteins: application to topology prediction 1 1Edited by J. ThorntonJournal of Molecular Biology, 1998
- A putative HCO−3 transporter in the cyanobacterium Synechococcus sp. strain PCC 79421FEBS Letters, 1998
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997