ADRENAL AND TESTICULAR CONTRIBUTION TO PLASMA OESTROGENS

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Abstract
SUMMARY: The concentration of oestrone (E1) and oestradiol (E2) in plasma was measured by a radioimmunological method. In five premenopausal women, ovariectomy provoked a significant fall in the concentrations of E1 and E2. In 11 subjects of both sexes with cancer, dexamethasone (20 μg/kg/day) caused a significant fall in the levels of cortisol (84 ± 9·5%) and E1 (55 ± 16%), but not in E2 (2 ± 18%). Ninety minutes after administration of tetracosactrin, the increase in concentration of cortisol (80 ± 30%) and of E1 (70 ± 49%) was highly significant: that of E2 (5 ± 12%) was not. Similar results were observed in four subjects during infusion of corticotrophin. In six subjects, plasma concentration of E1, androstenedione and dehydroepiandrosterone was higher in the adrenal vein than in a peripheral vein, but the concentration of E2 and of testosterone was similar in the two samples. In two men, the concentration of androgens and oestrogens was measured in plasma from a peripheral vein and in plasma of mixed origin from the renal and the spermatic vein. The level of E2 was higher in plasma from the renal—spermatic mixture than in that from the peripheral vein, but the concentration of E1 was similar. All these results suggest that: (1) the adrenal secretes only 17-oxo androgens and oestrogens whereas in the testicular secretion, 17β-hydroxylated compounds predominate; (2) in men, nearly all of the E2 is secreted directly or indirectly by the testes, but the main source of E1 is the adrenal; (3) in postmenopausal women, most of the E1 also derives from the adrenal gland.

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