Plasma Vasopressin Levels after Infusions of Hypertonic Saline Solutions into the Renal, Portal, Carotid, or Systemic Circulation in Conscious Dogs*

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Abstract
To determine whether extracerebral osmoreceptors contribute to vasopressin release when exposed to blood osmolality changes of .apprx. 1%, hypertonic saline solution was administered to 5 conscious dogs through catheters chronically implanted into the inferior vena cava, the portal vein, the artery to a sole remaining kidney and the common carotid arteries. Each infusion was given on a different day at a rate of 0.2 ml/min, which provided about 25 .mu.mol NaCl/kg BW [body wt] .cntdot. min. The changes in plasma Na concentration and plasma osmolality measured during these infusions were similar with all 4 routes of administration and significantly different from those after i.v. infusion of isotonic saline solution. Plasma vasopressin concentration, measured by RIA [radioimmunoassay], increased more rapidly after intracarotid infusions than with any other route. No evidence was found that renal or portal/hepatic osmoreceptors contributed to vasopressin release under the conditions of this study.

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