Pathogenicity of Chuzan virus, a new member of the Palyam subgroup of genus Orbivirus for cattle.

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Abstract
The pathogenicity of Chuzan virus, which is the putative causal agent of an epidemic of congenital abnormalities with the hydranencephaly-cerebellar hypoplasia syndrome of calves, was studied. All cattle inoculated intravenously with the virus showed leukopenia but no other clinical signs. The virus was recovered from the plasma only intermittently before development of virus neutralizing antibody, but was found persistently in erythrocyte fractions for several weeks. The virus was mostly found in the purified erythrocyte fraction and sometimes in the thrombocyte fraction, but not in leukocyte fractions. On the other hand, calves inoculated intracerebrally with the virus suffered a fatal infection which was characterized by severe nervous signs. Chuzan virus was isolated mainly from the cerebrum, midbrain, medulla oblongata and cerebellum of the calves, but not from other organs except lymphatic tissues of one animal.

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