INHIBITION OF HUMAN NEUTROPHIL CHEMOTAXIS BY CORTICOSTEROIDS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 8  (1) , 30-33
Abstract
A direct inhibitory effect of hydrocortisone on granulocyte chemotaxis was demonstrated with an increasing inhibition between concentrations of 5 .mu.g to 12.5 .mu.g per ml. Washing the granulocytes after incubation with hydrocortisone did not reverse the inhibitory effect on chemotaxis indicating a direct cellular effect. Bacteriocidal [Escherichia coli] capacity of the hydrocortisone treated cells was not reduced. Corticosteroids alter motility of granulocytes irreversibly, possibly by incorporation into the cell membrane.