THE STEREOSPECIFIC HYDROXYLATION OF ENDOCYCLIC ETHYLENIC LINKAGE IN THE BIOTRANSFORMATION OF α-TERPINYL ACETATE WITH CULTURED SUSPENSION CELLS OF NICOTIANA TABACUM

Abstract
The biotransformation of (±)-8-acetoxy-p-menth-1-ene (α-terpinyl acetate) with the cultured cells of Nicotiana tabacum was found to result in the predominant formation of 8-acetoxy-c-4-p-menthane-r-1,t-2-diol. This experimental result indicates that the hydroxylation of the endocyclic ethylenic linkage with the cultured suspension cells is stereospecific.