The purpose of this study was to investigate the intellectual, problemsolving, perceptual, psychomotor and motor impairment that occurs in patients (N = 11) with Huntington's chorea. In addition, comparison was made of the degree of emotional disturbance experienced by these patients as compared with a matched group with brain damage due to cerebrovascular disease or trauma who were equated for amount of neuropsychological impairment (Halstead's Impairment Index). Huntington's chorea seriously impaired not only motor and psychomotor abilities but also a broad range of higher mental functions which are not dependent upon motor skills. Huntington's chorea patients were found to have Minnesota Multiphasic Personality Inventory profiles (elevations on Hs, D, Sc) that were strikingly similar in level and pattern to those seen in the mixed brain-damaged group.