Effects of R 56 865, a Preventer of Cellular Calcium Overload, on Left Ventricular Diastolic Properties During Pacing-Induced Ischemia in Dogs

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Abstract
The effect, of R 56 865, a compound with unusual calcium antagonistic properties. on altered left ventricular (I. V) diastolic properties were studied during pacing-induced ischemia in dogs with coronary stenosis. Severe coronary artery stenosis was produced on hoth the left anterior descending (LAD) and circumflex (Cx) caronary arteries in anesthetized β-blocked dogs. The right atrium was paced at 200 heats min for 3min. In the postpacing period and before drug intervention, the most characteristic observation was a significant increase in LA end-diastolic pressure (LVEDP) and in the time constant of (7) LN pressure decrease: after return of LV he modynamies to baseline values (15 min), R 56 865 (0.16 mg. kg) or solvent (control) was injected and four subsequent pacing runs were performed at 30-min intevals. In the postpacing period of these four subsequent runs, there was a steep increase in LVEDP and -values while HR returned more slowly to baseline Values. After R 56 865 infusion. the increase in LVEDP and -values was significantly luvicer than in the pretreatment run and all LVEDP values were significantly lower than in the control group. We conclude that R 56 865 effectively attenuates ischemia-induced changes in LV diastolic stiffness.

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