5-Fluorouracil: Forty-Plus and Still Ticking. A Review of its Preclinical and Clinical Development
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- 1 November 2000
- journal article
- review article
- Published by Springer Nature in Investigational New Drugs
- Vol. 18 (4) , 299-313
- https://doi.org/10.1023/a:1006416410198
Abstract
5-Fluorouracil (5-FU) and 5-fluoro-2′-deoxyuridine (FdUrd) are pyrimidine analogs that have been partof the therapeutic armamentarium for a variety of solid tumorsfor over forty years. 5-FU has...Keywords
This publication has 118 references indexed in Scilit:
- Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic targetJournal of Molecular Biology, 1999
- Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle numberEuropean Journal Of Cancer, 1998
- The effects of 5-fluoropyrimidines on nascent DNA synthesis in Chinese hamster ovary cells monitored by pH-step alkaline and neutral elutionCarcinogenesis: Integrative Cancer Research, 1994
- Dihydropyrimidine dehydrogenase activity in cancer patientsEuropean Journal Of Cancer, 1993
- Synergism and Lack of Cross-resistance Between Short-term and Continuous Exposure to Fluorouracil in Human Colon Adenocarcinoma CellsJNCI Journal of the National Cancer Institute, 1993
- Ribonucleoprotein particle assembly and modification of U2 small nuclear RNA containing 5-fluorouridineBiochemistry, 1993
- A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1988
- Fluorouracil Therapy in Patients With Carcinoma of the Large BowelClinical Pharmacokinetics, 1978
- Purification and amino acid analysis of an active site peptide from thymidylate synthetase containing covalently bound 5-fluoro-2′-deoxyuridylate and methylenetetrahydrofolateBiochemical and Biophysical Research Communications, 1974
- Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory CompoundsNature, 1957