Apoptosis-based therapies
Top Cited Papers
- 1 February 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 1 (2) , 111-121
- https://doi.org/10.1038/nrd726
Abstract
Many of today's medical illnesses can be attributed directly or indirectly to problems with apoptosis--a programmed cell-suicide mechanism. Disorders in which defective regulation of apoptosis contributes to disease pathogenesis or progression can involve either cell accumulation, in which cell eradication or cell turnover is impaired, or cell loss, in which the cell-suicide programme is inappropriately triggered. Identification of the genes and gene products that are responsible for apoptosis, together with emerging information about the mechanisms of action and structures of apoptotic regulatory and effector proteins, has laid a foundation for the discovery of drugs, some of which are now undergoing evaluation in human clinical trials.Keywords
This publication has 110 references indexed in Scilit:
- SAFETY AND EFFICACY OF EXISULIND FOR TREATMENT OF RECURRENT PROSTATE CANCER AFTER RADICAL PROSTATECTOMYJournal of Urology, 2001
- Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in MiceScience, 2001
- Mechanisms of ApoptosisThe American Journal of Pathology, 2000
- Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic StimuliScience, 2000
- Pharmacological Rescue of Mutant p53 Conformation and FunctionScience, 1999
- An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9Journal of Biological Chemistry, 1999
- Mitochondria and ApoptosisScience, 1998
- KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor geneNature Genetics, 1997
- Structure of Bcl-x L -Bak Peptide Complex: Recognition Between Regulators of ApoptosisScience, 1997
- Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling PathwaysScience, 1997