Antiarrhythmic Effect of Reducing Myocardial Noradrenaline Stores with α-Methyl-Meta-Tyrosine
- 1 January 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 7, S81-S85
- https://doi.org/10.1097/00005344-198500075-00017
Abstract
In the adrenergic neurons the amino acid α-methyl-metatyrosine (α-MmT) is converted to metaraminol via the noradrenaline (NA) synthetic pathway. Metaraminol thereby displaces NA from its neuronal stores, and as a consequence NA levels can be drastically reduced, although normal sympathetic tone is essentially maintained by release of newly synthetized NA. In rats treated with α-MmT methylester (400 + 200 mg/kg) myocardial NA was reduced to 2 test) and mortality from 37 to 15% (p < 0.05). The results indicate an important role of myocardial NA stores in the development of early ischemic arrhythmias.Keywords
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