Relationship Between Isoniazid Resistance, Endogenous Catalase Activity and Guinea Pig Pathogenicity of Mycobacterium tuberculosis

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Abstract
Among typical human type tubercle bacilli and their isoniazid-resistant mutants, there is a relationship between the degree of isoniazid resistance and the magnitude of endogenous catalase activity; as the level of resistance to isoniazid increases, endogenous catalase activity decreases. At a given level of isoniazid resistance there is a decrease in pathogenicity for the guinea pig which is directly related to a decrease in catalase activity.