Control of endodermal endocrine development by Hes-1
Top Cited Papers
- 1 January 2000
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 24 (1) , 36-44
- https://doi.org/10.1038/71657
Abstract
Development of endocrine cells in the endoderm involves Atonal and Achaete/Scute-related basic helix-loop-helix (bHLH) proteins. These proteins also serve as neuronal determination and differentiation factors, and are antagonized by the Notch pathway partly acting through Hairy and Enhancer-of-split (HES)-type proteins. Here we show that mice deficient in Hes1 (encoding Hes-1) display severe pancreatic hypoplasia caused by depletion of pancreatic epithelial precursors due to accelerated differentiation of post-mitotic endocrine cells expressing glucagon. Moreover, upregulation of several bHLH components is associated with precocious and excessive differentiation of multiple endocrine cell types in the developing stomach and gut, showing that Hes-1 operates as a general negative regulator of endodermal endocrine differentiation.Keywords
This publication has 47 references indexed in Scilit:
- Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cellsDevelopment, 1998
- Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient miceGenes & Development, 1997
- Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.Genes & Development, 1997
- Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreasNature, 1997
- An achaete-scute homologue essential for neuroendocrine differentiation in the lungNature, 1997
- The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreasNature, 1997
- Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cellsNature, 1997
- Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix ProteinScience, 1995
- Insulin-promoter-factor 1 is required for pancreas development in miceNature, 1994
- Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neuronsCell, 1993