Effects of Radiation on Tissue Serotonin Levels in the Rat.

Abstract
Rats exposed to a single dose of 900 r total body X-irradiation exhibited a highly significant reduction 6 days after X-irradiation in the serotonin concentration of the blood and spleen and a marked increment in serotonin concentration of the small intestine compared to values obtained in untreated ad libitum-fed and pair-fed controls. A significant reduc-tion in serotonin concentration in the spleen was also observed in rats exposed to gamma radiation. No significant difference in brain serotonin concentration was observed between X-irradiated and gamma-irradiated rats and untreated pair-fed controls but values for all 3 groups were reduced below that of untreated, ad libitum-fed controls.

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