TREATMENT OF CUSHING’S SYNDROME WITH AMPHENONE: REPORT OF TWO CASES, ONE WITH PROBABLE THYMOMA

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Abstract
Two patients with Cushing''s syndrome were treated with amphenone before undergoing adrenal surgery. One of these patients also had an anterior superior mediastinal neoplasm of probable thymic origin. The other suffered from severe mental depression, and manifested unusual adrenal sensitivity to corticotropin. The administration of amphenone in each case resulted in decreased formation and excretion of glucocorticoids, as shown by changes in the levels of 17-hydroxycorticoids in the plasma and urine, as well as other metabolic and biochemical effects secondary to these changes. In Case 1, during intravenous infusion of amphenone, urinary 17-ketosteroids were unchanged; during oral therapy they were depressed less than the corticoids. In Case 2, during oral therapy, urinary 17-ketosteroids were depressed, but more slowly than the corticoids.