Rapid Synthesis of Matrix Metalloproteinase Inhibitors via Ugi Four-Component Condensation

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Abstract
By employing ammonia, together with a mono succinate ester, an aldehyde and an isonitrile in the Ugi four-component condensation the basic structure of pseudopeptide succinyl matrix metalloproteinase inhibitors is constructed in a single step. Deprotection of the ester provides the carboxylic acid zinc(II) binding group required for biological activity.

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