Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties
- 15 October 2008
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 18 (20) , 5439-5442
- https://doi.org/10.1016/j.bmcl.2008.09.023
Abstract
No abstract availableKeywords
This publication has 21 references indexed in Scilit:
- Novel Selective Allosteric Activator of the M1Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in RatsJournal of Neuroscience, 2008
- Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for SchizophreniaAmerican Journal of Psychiatry, 2008
- Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffoldBioorganic & Medicinal Chemistry Letters, 2008
- Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: Optimization of the 4-substituted piperidineBioorganic & Medicinal Chemistry Letters, 2006
- DystoniaNew England Journal of Medicine, 2006
- M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic MiceNeuron, 2006
- Probing the Molecular Mechanism of Interaction between 4-n-Butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the Muscarinic M1 Receptor: Direct Pharmacological Evidence That AC-42 Is an Allosteric AgonistMolecular Pharmacology, 2006
- Development of a Custom High-Throughput Preparative Liquid Chromatography/Mass Spectrometer Platform for the Preparative Purification and Analytical Analysis of Compound LibrariesJournal of Combinatorial Chemistry, 2003
- Muscarinic receptors: it's a knockoutTrends in Pharmacological Sciences, 2001
- Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genesNeuron, 1988