Novel guaiane- and secoguaiane-type sesquiterpenes from Alpinia japonica (THUNB.) MIQ.

Abstract
Three novel guaiane-type sesquiterpenes, hanalpinone (I), isohanalpinone (II), and alpinenone (III), and two novel secoguaiane-type sesquiterpenes, alpinolide peroxide (IV) and 6-hydroxyalpinolide (V) have been isolated from the rhizomes of Alpinia japonica. Their structures were determined by spectroscopic methods, chemical conversions, and X-ray analysis. Their biosynthetic relationships with previously identified sesquiterpenes from Alpinia japonica are discussed.

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