REACTION OF THE CARCINOGEN DIMETHYLNITROSAMINE WITH PROTEINS AND WITH THIOL COMPOUNDS IN THE INTACT ANIMAL
- 1 February 1965
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 94 (2) , 323-330
- https://doi.org/10.1042/bj0940323
Abstract
[C14]Dimethylnitrosamine was administered to rats, and the formation of free and protein-bound S-methylcysteine was investigated. Very little S-methylcysteine was found in liver acid-soluble fraction, in liver protein or in urine. The methylhistidines formed in liver protein were found to have largely disappeared by 6 days after injection of dimethylnitrosamine. The significance of these results in the carcinogenic action of dimethylnitrosamine is discussed.Keywords
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