Response to hypercapnia under ketamine anaesthesia
- 1 July 1975
- journal article
- research article
- Published by Springer Nature in Canadian Journal of Anesthesia/Journal canadien d'anesthésie
- Vol. 22 (4) , 486-494
- https://doi.org/10.1007/bf03004864
Abstract
The respiratory response to hypercapnia in dogs anaesthetized with ketamine was increased. This respiratory stimulation was most probably due to a direct effect of the drug on the medullary respiratory neurones. This effect was not modified by preanaesthetic medication pentobarbitone 5 mg/kg or morphine 0.1 mg/kg. Catecholamine response to hypercapnia was essentially the same as that reported by hypercapnic dogs anaesthetized with thiopentone. La réponse ventilatoire à l’hypercapnie provoquée chez des chiens anesthésiés à la kétamine est augmentée. Cette stimulation respiratoire est, selon toute probabilité attribuable à l’effet direct du médicament, sur les centres respiratoires médullaires. Une prémédication au pentobarbitone (5 mg/kg) ou à la morphine (0.1 mg/kg) n’a pas modifié cette réaction. Le taux de catécholamines lié à l’hypercapnie est essentiellement le même chez les chiens anesthésiés à la kétamine ou au thiopentone.Keywords
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