Role of Cyclic AMP in the Natriuresis of Extracellular Fluid Volume Expansion in the Dog

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Abstract
The effect of extracellular volume expansion (ECVE) on renal production of cyclic[c]AMP was evaluated in 19 thyroparathyroidectomized dogs. ECVE was produced by infusion of Ringer bicarbonate solution at a rate of 2 ml min-1 kg-1 body wt; cAMP was measured in plasma obtained from the aorta and renal vein and in the urine. During the natriuresis of ECVE, urinary excretion of cAMP, clearance of cAMP, net nephrogenous cAMP added to the urine and to the renal vein, and hence, total nephrogenous cAMP increased significantly. This rise in net production of cAMP and a significant natriuresis by the kidney persisted for 60-90 min after discontinuation of active ECVE and return of renal plasma flow to normal. An increase in production of cAMP by the kidney may play a role in natriuresis of ECVE.