Liquid Chromatographic and Mass Spectral Analysis of Methoxyamphetamines and Methoxymethamphetamines

Abstract
The 2-, 3-, and 4-methoxyamphetamines and methoxymethamphetamines were prepared by reductive amination of the corresponding ketones. The compounds have a wavelength of maximum absorption in the ultraviolet range around 271 nm and a molar absorptivity of 1.0 × 103 L/mol-cm. The compounds were separated by reversedphase chromatography with a C18 stationary phase and acidic aqueous acetonitrile mobile phase. The mass spectra showed the amine-dominated fragmentation pattern with molecular ions of very low relative abundance.

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