The relationship of parathyroid activity to pyrophosphate excretion.

Open Access
Publisher Website
Google Scholar
Abstract
Parathyroid extract administration to normal subjects and patients with hypoparathyroidism caused a significant increase in urinary pyrophosphate that reverted to pretreatment values when therapy was discontinued. A 4-hr, constant infusion of Ca produced a prompt fall in pyrophosphate excretion in normal subjects but not in hypoparathyroid patients. Unilateral renal arterial perfusion with parathyroid extract in dogs resulted in a significant prompt rise in orthophosphate and a delayed rise in pyrophosphate excretion. The latter coincided with corresponding delayed increments in orthophosphate, hydroxyproline, and pyrophosphate excretion in the contralateral control saline-perfused kidney. These observations suggest that pyrophosphate excretion is regulated by parathyroid activity and that this regulation is mediated through alterations in bone resorption.