Drug Allergy

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Abstract
Laboratory DiagnosisThe fact that there is no single, universally applicable test for drug allergy is not surprising since a number of different pathogenetic mechanisms can lead to allergic symptoms. In penicillin allergy, and to a lesser extent in other types of drug allergy, antibodies can often be detected by direct skin testing. Anaphylactic sensitivity is indicated by the development of a wheal and erythema skin response. A positive reaction usually reaches maximal intensity within a matter of 15 to 20 minutes, making routine skin testing immediately before drug therapy a practical possibility. Even when marked . . .