Effect of Glucose on Growth Hormone, Prolactin and Thyroid-Stimulating Hormone Response to Diazepam in Normal Subjects

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Abstract
The effect of hyperglycemia on growth hormone, thyroid-stimulating hormone, and prolactin response to oral diazepam (10 mg) was assessed in 7 normal subjects. A peak growth hormone response of 13.5 ± 0.3 ng/ml (mean ± SEM) significantly above the base line (p < 0.001) was achieved when diazepam was given alone. Hyperglycemia after glucose load abolished this response. There was no significant response of thyroid-stimulating hormone or prolactin after the administration of oral diazepam with and without glucose.