MODULATION OF PLATELET CYCLIC NUCLEOTIDE CONTENT BY PGE-1 AND PROSTAGLANDIN ENDOPEROXIDE PGG-2

  • 1 January 1976
    • journal article
    • research article
    • Vol. 2  (2) , 79-87
Abstract
The effects of prostaglandin E1 [PGE1] and PGG2, the PG endoperoxide, on [human] platelet cyclic nucleotide concentrations were measured in platelet rich plasma (PRP) and in washed intact platelets. PGE1 was a potent stimulator of platelet c[cyclic]AMP levels in both PRP and washed cells and inhibited aggregation in both systems. PGE1 did not change platelet cGMP levels in either PRP or washed cells. PGG2, a potent inducer of platelet aggregation, did not affect either the basal cAMP or the basal cGMP concentration. PGG2 antagonized the increases in cAMP content in response to PGE1 in both PRP and washed platelets. The addition to the system of a cyclic nucleotide phosphodiesterase inhibitor, theophylline, did not change the findings. PGG2 may induce platelet aggregation by inhibiting PGE1-stimulated cAMP accumulation.

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