Surface Ultrastructural Changes in Granulosa Cells of Atretic Follicles1

Abstract
In nonatretic antral ovarian follicles of the rat, adjacent granulosa cells were in close contact, spherical in shape, and possessed irregular cytoplasmic evaginations. As the follicle became atretic, the intercellular space between the granulosa cells increased and these cells became flattened and lost their cytoplasmic evaginations. In advanced stages of atresia aggregates of granulosa cells were attached to follicular basement membrane.

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