LY146032: activity and resistance development in vitro
- 1 October 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 20 (4) , 513-517
- https://doi.org/10.1093/jac/20.4.513
Abstract
LY 146032, a new lipopeptide antibiotic, was compared with vancomycin, teicoplanin, cefamandole and ciprofloxacin, against 107 clinical isolates comprising methicillin-susceptible and methicillin-resistant Staphylococcus spp., Streptococcus faecalis and Corynebacterium spp. All staphylococci were susceptible to all agents, except that some of the methicillin-resistant strains were resistant to cefamandole. Only LY 146032 and ciprofloxacin were bactericidal to Str. faecalis. Development of resistance was studied by serial transfers of ten selected strains. A stable ≥ eightfold increase of the MIC over the breakpoint was found to develop to a variable extent against all agents tested. Simultaneous development of resistance to any of the other antibiotics was registered in 11/200 tests.Keywords
This publication has 2 references indexed in Scilit:
- In vitro activity of LY146032 (Daptomycin), a new peptolideEuropean Journal of Clinical Microbiology & Infectious Diseases, 1987
- In vitro and in vivo activity of LY 146032, a new cyclic lipopeptide antibioticAntimicrobial Agents and Chemotherapy, 1986