Abstract
Theoretical formulations concerning the cause, nature, and mode of treatment of schizophrenia are many. In actuality, however, there are currently three major formulations. One is a physiological concept based essentially on the principle of autointoxication, in which, although no specific factor has been found, there is a feeling that one will soon be found. Each year a new outcropping of possibilities appears, most of which readily yield their promise or appear to be simply correlates of an ongoing situation.1-4 Another formulation regarding schizophrenia, particularly etiology, seems to be the ubiquitous one of a congenital illness, primarily based on studies of twinning.5,6One area of comparative evidence for this is the model of Friedreich's cerebellar ataxia, which is an irreversible process, as might be expected of an illness of this type. In effect, the congenital or hereditary hypothesis is a rather indirect way of imputing a physiological base to

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