Asymmetric aziridine synthesis via aza-Darzens reaction of bromoacylcamphorsultam
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 23,p. 2631-2632
- https://doi.org/10.1039/cc9960002631
Abstract
The aza-Darzens reaction of the chiral enolate derived from bromoacetylcamphorsultam 1 with N-(diphenyl-phosphinyl)aryl- and tert-butyl-methanimines proceeds in good yield to give cis-N-(diphenylphosphinyl)aziridinylcarbonyl sultams with high de. Monochiral cis-aziridinecarboxylates may be obtained in acceptable yield by hydrolysis of these sultams.Keywords
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