Haemodialysis and Hypothalamo-Pituitary-Testicular Axis

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Abstract
Disturbances in testicular function develop in uremic patients, but the effect of hemodialysis on them was not determined definitively. Because of this, 22 patients with chronic renal failure who were receiving regular dialysis treatment underwent studies of the hypothalamo-pituitary testicular axis before, during and after a dialysis. On all these occasions, serum testosterone concentrations were lower than the values found in 26 normal men. Serum concentrations of FSH and lutropin were higher than normal. Thirteen of these patients showed a normal response of the hypothalamo-pituitary system to the clomiphene stimulation test and a diminished response of Leydig''s cells to the human chorionic gonadotropin stimulation test. Hemodialysis apparently does not affect the impaired gonadal function of male uremic patients.
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