Intramuscular Injection of Drugs

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Abstract
Drugs have been administered by intramuscular injection for more than a century. This route of administration is most useful when the patient's disease or the pharmacokinetic properties of the drug preclude oral dosing. The technic of intramuscular injection is straightforward,1 and such injections are generally thought to be less hazardous than intravenous infusions. They are routinely administered by nurses, by other nonphysician medical personnel or even by patients to themselves. Most physicians assume that the intramuscular route is as reliable as the intravenous and that it results in equally complete bioavailability of the injected drug.The popularity of intramuscular injections . . .

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