Factor IX Deficiency and Prolonged Bleeding Time

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Abstract
VON Willebrand's disease is manifested by a deficiency of factor VIII (antihemophilic factor) and a prolonged bleeding time and is inherited as an autosomal dominant trait of variable penetrance.1 Such patients are characterized by a prolonged rise in plasma factor VHIin response to transfusion with either normal or hemophilia A plasma,1 , 2 and their platelets show a diminished ability to adhere to glass.3 The association of a prolonged bleeding time with a deficiency of factor IX (plasma thromboplastin component) has occasionally been reported,4 5 6 7 and a prolonged bleeding time has also been described with a deficiency of factor X (Stuart-Prower)8 or factor . . .