Analog Inhibitors for the Pyrophosphate-Dependent Phosphofructokinase of Entamoeba histolytica and their Effect on Culture Growth
- 1 August 1982
- journal article
- research article
- Published by JSTOR in Journal of Parasitology
- Vol. 68 (4) , 599-602
- https://doi.org/10.2307/3280916
Abstract
Diphosphonate substrate-analogs of inorganic pyrophosphate (PPi) [1,1-diphosphonate, nonane, ethylene, hydroxymethane, 2-aminoethane and 1-hydroxyethane] were found to be competitive inhibitors for amoebal PPi-dependent phosphofructokinase. Analogs of the phosphoryl donor were employed in in vitro growth tests. All appeared to inhibit amoebal growth; one was amoebistatic at a concentration of 1 mM. Pyrophosphate analogs are, potentially, therapeutic agents for intestinal amoebiasis [in humans].This publication has 1 reference indexed in Scilit:
- 6-phosphofructokinase (pyrophosphate). Properties of the enzyme from Entamoeba histolytica and its reaction mechanism.Journal of Biological Chemistry, 1976