Reprogramming of genome function through epigenetic inheritance
Open Access
- 1 November 2001
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 414 (6859) , 122-128
- https://doi.org/10.1038/35102186
Abstract
Most cells contain the same set of genes and yet they are extremely diverse in appearance and functions. It is the selective expression and repression of genes that determines the specific properties of individual cells. Nevertheless, even when fully differentiated, any cell can potentially be reprogrammed back to totipotency, which in turn results in re-differentiation of the full repertoire of adult cells from a single original cell of any kind. Mechanisms that regulate this exceptional genomic plasticity and the state of totipotency are being unravelled, and will enhance our ability to manipulate stem cells for therapeutic purposes.Keywords
This publication has 71 references indexed in Scilit:
- Imprinting and the Epigenetic Asymmetry Between Parental GenomesScience, 2001
- Re-SET-ting heterochromatin by histone methyltransferasesTrends in Cell Biology, 2001
- Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domainNature, 2001
- Genomic imprinting: parental influence on the genomeNature Reviews Genetics, 2001
- Active demethylation of the paternal genome in the mouse zygoteCurrent Biology, 2000
- Demethylation of the zygotic paternal genomeNature, 2000
- Methylation-Induced Repression— Belts, Braces, and ChromatinPublished by Elsevier ,1999
- Eight Calves Cloned from Somatic Cells of a Single AdultScience, 1998
- Full-term development of mice from enucleated oocytes injected with cumulus cell nucleiNature, 1998
- Viable offspring derived from fetal and adult mammalian cellsNature, 1997