PHARMACOKINETICS OF VALPROIC ACID AFTER ORAL AND INTRAVENOUS ADMINISTRATION
Open Access
- 1 April 1978
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 5 (4) , 313-318
- https://doi.org/10.1111/j.1365-2125.1978.tb01713.x
Abstract
1 The kinetics of sodium valproate (di-n-propyl-acetate, Depakine®) have been studied in six healthy volunteers after administration of single oral and intravenous doses (800 mg). 2 Kinetic parameters were similar for both routes of administration. In all subjects absorption was rapid and complete. Half-lives ranged from 11–15 h. Apparent volumes of distribution were relatively low (0.147 ± 0.0041/kg) and showed little variation amongst individuals. 3 The factors responsible for the poor correlation between dosage and serum levels during chronic treatment and therapeutic implications are discussed.Keywords
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