Cytopathic Effects Of Pathogenic And Nonpathogenic Species Of Candida On Cultured Mouse Epithelial Cells: Relation To The Growth Rate And Morphology Of The Fungi

1 February 1969

journal article
Published by Microbiology Society in Journal of Medical Microbiology

Vol. 2 (1) , 63-74
https://doi.org/10.1099/00222615-2-1-63

Abstract

The cytopathic effects of standard inocula (30,000 blastospores per ml) of Candida albicans, C. tropicalis, C. stellatoidea, C. krusei, C. pseudotropicalis, C. parapsilosis and C. guilliermondii (isolated from man) on murine renal epithelial cells in culture were compared with those of C. cacaoi, C. diddensii, C. kefyri, C. blankii, C. ingens and C. shehatae (isolated from non-human sources). The nature of the changes in the mammalian cells, and the extent of their destruction, were shown to be correlated with the growth rate and with the proportion of mycelium in the growing fungi. The presence of mammalian cells induced filamentous change in some species.

Keywords

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