Meningeal Involvement in Wegener's Granulomatosis Confirmed and Monitored by Positive Circulating Antineutrophil Cytoplasm in Cerebrospinal Fluid

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Abstract
MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activity by c-ANCA measurement in the CSF. After repeated cycles of intrathecal administration of methotrexate and corticoids, progression of meningeal infiltration stopped, and CSF c-ANCA titers became negative. NEUROLOGY 1997;48: 263-265