Trisomy of the Long Arm of Chromosome #1 in Human Leukemia
- 1 January 1976
- journal article
- case report
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 56 (1) , 183-184
- https://doi.org/10.1093/jnci/56.1.183
Abstract
We encountered a karyotypic abnormality, i.e., a trisomy of part of or the whole long arm of chromosome #1, in 4 patients with leukemia: 3 with acute myeloblastic leukemia (AML) and 1 with chronic myelocytic leukemia (CML) in the blastic phase. Q- and G-banding techniques revealed that in two patients with AML and in the one with CML, this karyotypic abnormality was not an initial one and was apparently associated with clinical progression of the disease. This chromosome change is a common karyotypic abnormality in blood disorders, especially in AML, and possibly bears a relationship to selective growth advantages of the leukemia cells.Keywords
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