Migraine Provoked by Aspartame

Publisher Website
Google Scholar
Abstract
To the Editor: Aspartame (NutraSweet) is an artificial sweetener that is 150 to 200 times sweeter than sucrose and is a dipeptide composed of the methyl ester of phenylalanine and aspartic acid.1 It was approved for use in carbonated beverages in July 1983, and a marked rise in aspartame-related complaints to the Food and Drug Administration followed, with neurologic and behavioral symptoms (including headache) being the most common cause of complaints.2 Dietary substances, including phenylethylamine, tyramine, and nitrites, have been noted to have a role in migraine headache.3 4 5 The following case suggests the possibility that aspartame may act as such . . .

This publication has 7 references indexed in Scilit: