Peelfit: An Integrated Computer Program for Pharmacokinetic Analysis

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Abstract
An Integrated program PEELFIT is reported for the Apple IIe microcomputer, which performs pharmacokinetic analysis for intravenous and first order absorption (oral or intramuscular) data. PEELFIT, written in basic language, uses plasma concentration and time for input. Upon the user's choice, it carries out non-linear regression on the data for curve fitting, according to a one or two compartment model. the curve fitting can be done with three weighting schemes. Parameters of the plasma concentration equations are obtained from the regression analysis and further, these are employed to calculate the relevant pharmacokinetic parameters. Finally, the percentage of dose absorbed (absorbable fraction) is calculated as a function of time. various known data were analysed with PEELFIT and the results obtained confirmed its accuracy.

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