EFFECTS OF DROPERIDOL ON THE VASOCONSTRICTION PRODUCED BY NORADRENALINE, HISTAMINE, SYMPATHETIC NERVE STIMULATION AND POTASSIUM IONS IN THE ISOLATED RABBIT AURICULAR ARTERY
Open Access
- 1 May 1971
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 43 (5) , 441-444
- https://doi.org/10.1093/bja/43.5.441
Abstract
Droperidol consistently blocked the vasoconstriction induced by noradrenaline, histamine and sympathetic nerve stimulation in concentrations between 0.01 and 10 μg/ml in the isolated rabbit auricular artery preparation. Vasoconstriction induced by potassium ions was blocked in all concentrations of droperidol but less at the highest concentration. It is postulated, therefore that droperidol is a non-specific inhibitor of vasoconstriction rather than a competitive alpha-adrenergic receptor blocking agent.Keywords
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