Luteolytic effect of 13,14-dihydro-PGF-2 in heifers

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Abstract
Holstein heifers (4/group) were injected i.m. with 0, 5, 10 or 25 mg 13,14-dihydro-PG[prostaglandin]F-2.alpha. on day 10 of the estrous cycle. Complete luteolysis and precocious estrus occurred in 3 of 4 heifers receiving 25 mg and 1 of 4 receiving 10 mg 13,14-dihydro-PGF-2.alpha. injected i.m. These features were not affected in heifers injected with 0 or 5 mg 13,14-dihydro-PGF-2.alpha., although plasma proesterone concentrations were depressed in all treated heifers within 75 min. LH [luteinizing hormone] concentrations were elevated between 5 and 8 h after 13,14-dihydro-PGF-2.alpha. in all treated heifers. The addition of 13,14-dihydro-PGF-2.alpha. to dispersed bovine luteal cells did not affect progesterone accumulation during a 2-h period. Apparently, 13,14-dihydro-PGF-2.alpha. may play a role in PGF-2.alpha.-induced luteolysis.