Antiviral Terpenoid Constituents of Ganoderma pfeifferi

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Abstract
Four sterols and 10 triterpenes were isolated from the fruiting bodies of Ganoderma pfeifferi, including the three new triterpenes 3,7,11-trioxo-5α-lanosta-8,24-diene-26-al (lucialdehyde D, 1), 5α-lanosta-8,24-diene-26-hydroxy-3,7-dione (ganoderone A, 2), and 5α-lanosta-8-ene-24,25-epoxy-26-hydroxy-3,7-dione (ganoderone C, 3). The structures of 1−3 were determined on the basis of spectroscopic evidence. Antibacterial, antifungal, and antiviral activity were studied for some of the isolated compounds. Ganoderone A (2), lucialdehyde B (4), and ergosta-7,22-dien-3β-ol (7) were found to exhibit potent inhibitory activity against herpes simplex virus.