Nuclear Factor-KB as a Common Target and Activator of Oncogenes in Head and Neck Squamous Cell Carcinoma

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Abstract
Head and neck squamous cell carcinomas exhibit alterations in cell proliferation, survival (apoptosis), migration, angiogenesis and inflammation. The transcription factor nuclear factor-KappaB integrates multiple signals and regulates expression of multiple genes involved in these phenotypic responses, suggesting the hypothesis that nuclear factor-KappaB is an important molecular switch for development of head and neck squamous cell carcinoma. Nuclear factor-KappaB has been found to be constitutively activated, and a common target and activator of oncogenes in cancer. Because of its important role, activation of nuclear factor-KappaB by the proteasome and other signal molecules may provide targets for molecular therapy of squamous cell carcinoma and other cancers.

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