Lactic Acid Polymers as Biodegradable Carriers of Fluoroquinolones: An In Vitro Study
- 1 March 1999
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 43 (3) , 714-716
- https://doi.org/10.1128/aac.43.3.714
Abstract
A biodegradable polymer of dl -dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described. Duration and peak of release were found to depend on the molecular weight of the polymer. Its characteristics make it promising for treating chronic bone infections.Keywords
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