The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization
Top Cited Papers
- 1 October 2005
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 20 (5) , 349-356
- https://doi.org/10.1152/physiol.00025.2005
Abstract
The bone marrow vasuclar niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.Keywords
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